Scientists Identify the Molecular Binding Site of the Drug Niclosamide on TMEM16 PROTEINS

February 10, 2022. Scientists at the University of California, San Francisco identify the molecular binding site of niclosamide on TMEM16 by high resolution cryo-electron microscopy.  We are delighted with this new study describing the structure of niclosamide in a complex with TMEM16 proteins that extends our discovery in 2019 of the first molecular target for this drug, which represents a promising new treatment for respiratory disease.  This new research by Y. Cheng and associates at UCSF was published as a pre-print in the journal Research Square (DOI: