Our Innovation
We've focused on a new target, a proven drug and an innovative approach for drug delivery
The Right Target
An ion channel that controls the core features of disease in airway cells
TMEM16 is an ion channel expressed on airway smooth muscle, airway epithelial and other lung cells. When activated, TMEM16 amplifies calcium signaling that promotes epithelial-derived inflammation and the primary sources of obstruction: namely smooth muscle tightening and too much mucus. In fibrotic disease, TMEM16-mediated calcium signals promote pathologic fibrotic remodeling. Thus, inhibiting TMEM16A with AR-001 offers new approach to block all these disease processes.
The Right Molecule
Niclosamide is a proven drug that inhibits TMEM16 calcium signaling
Niclosamide has been used safely for years to treat illness in the gut. The new science that we're following points to enormous potential to treat obstructive lung disease by blocking our ion channel target. Importantly, structural and electrophysiology studies have confirmed target binding and inhibition of TMEM 16 function.
The Right Target
An ion channel that controls the core features of disease in airway cells
TMEM16 is an ion channel expressed on airway smooth muscle, airway epithelial and other lung cells. When activated, TMEM16 amplifies calcium signaling that promotes epithelial-derived inflammation and the primary sources of obstruction: namely smooth muscle tightening and too much mucus. In fibrotic disease, TMEM16-mediated calcium signals promote pathologic fibrotic remodeling. Thus, inhibiting TMEM16A with AR-001 offers new approach to block all these disease processes.
The Right Molecule
Niclosamide is a proven drug that inhibits TMEM16 calcium signaling
Niclosamide has been used safely for years to treat illness in the gut. The new science that we're following points to enormous potential to treat obstructive lung disease by blocking our ion channel target. Importantly, structural and electrophysiology studies have confirmed target binding and inhibition of TMEM 16 function.
The Right Particle
Our engineered drug particles deliver drug to the site of disease - only where it's needed and not where it isn't needed.
Supercritical Precipitation (SCP) is a best-in-class technology for generating small particle dry powder formulation. When combined with a proven and easy-to-use delivery technology this will create airborne particles that flow via inhalation to reach the target in the lungs and provide maximum efficacy.
The Right Particle
Our engineered drug particles deliver drug to the site of disease - only where it's needed and not where it isn't needed.
Supercritical Precipitation (SCP) is a best-in-class technology for generating small particle dry powder formulation. When combined with a proven and easy-to-use delivery technology this will create airborne particles that flow via inhalation to reach the target in the lungs and provide maximum efficacy.
