TMEM16 is an ion channel expressed on airway smooth muscle and airway epithelial cells. When activated in disease, TMEM16 causes excessive calcium signaling that promotes inflammation and the primary sources of obstruction: namely smooth muscle tightening and too much mucus.
Supercritical Precipitation (SCP) is a best-in-class technology for generating small particle dry powder formulation. When combined with a proven and easy-to-use delivery technology this will create airborne particles that flow via inhalation to the reach the target in the lungs and provide maximum efficacy.
Only target to alleviate all major causes of poor breathing: smooth muscle tightening, excess mucus and upstream inflammatory signals
Learn MoreOur lead program niclosamide is a potent TMEM16 inhibitor and an approved oral drug with a history of safety in humans
Learn MoreInhalation delivery of particles generated by supercritical precipitation provides superior target coverage
where it's needed: in the lungs.